NSAS Idea Suggestion #20 - Engineering Lactic Acid Bacteria To "Vaccinate" Against HIV

in nsas •  2 years ago 

In this series I propose daily ideas for new members who are interested in becoming #steemstem authors.

NSAS: New STEM Authors Support

I will post an idea a dayish (it is the goal to post daily, but again real life>steemit for now). With this idea I will include a short description about aspects you may be interested in. If you read this idea proposal, and you like it, and you want to write about it:

Go to the comments and write: "I, username, claim this idea"

Obviously "username" is where you write your own username. This is so that I know who is interested in @steemstem and science in general and I am always looking for a good read. This is honor system stuff, so please respect someone claiming an idea. Again, this is just the first step towards writing a good science post. There is more to it. Do your research, use scientific sources and try to use some proper language and attractive design.
This series will have their own hashtag #nsas, so that you can go back and sort through some of the ideas I have shared and what people made out of it. If you decide to use the idea I propose, please also include #nsas on your posts so that I can have a look at it and maybe get you connected in the steemstem group.
Please also visit @steemstem on steemit as well as on Discord. Follow the guidelines and appreciate the community. That means engage, upvote and comment until your fingers bleed.


Public Domain - Link

Engineering Lactic Acid Bacteria To "Vaccinate" Against HIV

Cheese and HIV. Seems like a weird combination. But some scientific effort is being made to use bacteria that are capable of lactic acid fermentation (so called lactic acid bacteris - LAB) as vectors for mucosal vaccination. The mucosal layer is found in many areas of our body, going from the oral and nasal cavities to the intestine and vagina. Advances in molecular biology and biotechnology allow us to engineer LABs to express antigens specific to a pathogen and use them as vaccine vectors. This has several advantages over the "classical" vaccination with needles.
For this post you will have to read about the use of LABs in mucosal vaccines, as well as biotechnology. You can write about how DNA vectors can be used to transform competent cells to produce and express antigen of choice. There are even ways to deliver the antigen to specific locations in the cell (example cell wall). An interesting question to answer in the early post is "Why mucosal vaccines with LABs?". People may be worried about using live bacteria as vaccines, that is something you should touch on. There are still many challenges to be overcome before this technology has come to fruition. I read in a current research article that this is still in the proof-of-concept phase. It should be one of your focuses to talk about shortcomings and problems that need to be addressed.
This topic is very interesting and there are many free publications available. The ones below should help to get you started.

  • Lactic acid bacteria: reviewing the potential of a promising delivery live vector for biomedical purposes - Link
  • Lactic acid bacteria—20 years exploring their potential as live vectors for mucosal vaccination - Link
  • HIV Inhibition by Lactobacilli: Easier in a Test Tube Than in Real Life - Link
  • Bioengineering Lactic Acid Bacteria to Secrete the HIV-1 Virucide Cyanovirin - Link

It seems that some people still do not understand that these are Idea Suggestions. If you think my description of this topic is too short, incomplete or if I gotten something wrong write a post about this topic. That is the reason why I am maintaining this series. I want to help you find ideas to write about.

Previous Idea Suggestions:

Helpful Links

  • How To Find Scientific Sources For Free - Post
  • SteemSTEM Guidelines - Link
  • Everything You Need to Know about Uploading Images on Steemit [Tutorial & MarkDown] – Link - by @katerinaramm


As always,
Cheers @lesshorrible!

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This approach is so weird. Maybe weird enough to succeed.

And I want to debunk this steemit article: How wifi is slowly killing you?

Something similar has been tested in human trials. Delivery of therapeutic small molecules using LAB who settle in the intestine. I dont have the study at hand and I have exam week, but I am sure you can find it relatively easy if you look for it.
Looking forward to that!

Hey @lesshorrible
The idea suggestion seems interesting, I think I can write on this after getting proper information on it.

"I @micro24 claim this idea."

Aswesome. Since you are a microbiologist I am really looking forward to your post! Take all the time you need. Cheers!

Ps: I have my microbiology final exam today:D

Best of luck for that

Somehow I hadn't heard about the #nsas initiative before, I think it's a great idea. Thanks for helping finding news ways to encourage good content.

Yeah you are welcome! Thank you for highlighting this and one of the resulting nsas posts (David Rhodes´post on bread) in your most recent publication. Following you now! Cheers!

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