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I reply to people who add value to the article I worked on and I support the minnows who comment on my post and also produce post that I like. People who comment with a couple words then ask for me to upvote and follow, the seek rewards while doing little work regarding the comments or post will get flagged and I will not upvote their post. This is common sense.

I probably flag to little too, note to self, but I report most spam to the steemcleaners.

A lot of the automatic bots are annoying too, adding useless price info or like in a comment.
Here's last example from one of my posts:

This is pure comment spam.

Don't do that if you'r going to succeed on Steemit 🙄