Hey @lemouth,

it's fine that you are enjoying my pix.

Concerning your question:

This corresponds to a huge fraction of the population, doesn’t it? But I guess those numbers account both from the positive mutations and negative ones altogether (cf. your point 1).):

No, the number corresponds primarily to category 2. & 4.

Everyone belongs to category 1., that's your heritage and in general, you don't suffer from them.
Nevertheless, it is a variation in function and could, therefore, be a potential problem.

But you are right 1 in 2000 are a lot and there are much more people affected because this is a number belongs to clear characterized mutations. Other problems are not taken into account thus far!

Regards,

Chapper