It is really interesting for to have something like protein, which have a meta-stable structures. It is so unbelievable that beta-sheet is so stable and which Alzheimer is take place when some protein fragment eventually arranged in beta-sheet aggregate.
I was told that there are chemist next to our lab, doing protein synthesis, had synthesized several enzymes in lab, but surprisingly they don't have activity. One had been explained that they are misfolded.
Misfolded proteins are a pain in the ass. I once did some research on the transport of misfolded proteins on the ER membrane in yeast cells. Sadly, no conclusive results.