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Thank you. Is there a way to invest in these by depositing USD or can you only do it by purchasing other coins first?

Make sure you are fully verified before depositing anything into Bittrex

I've used Coinbase and Kraken to deposit "real" USD. IMO, Coinbase is easier and if you set up an account at GDAX (uses your Coinbase credentials) you can buy without the high fees. I'm on the fence regarding Kraken as their website and trading platform has been unreliable.

I've only used Bittrex for trading coins. I do not trust Tether since it's not clear to me if it is actually backed by real USD so I avoid trading any pairs matched to USDT and instead tend to use the BTC pairs.

Coin Marketplace

STEEM 0.17
TRX 0.13
JST 0.027
BTC 61059.95
ETH 2677.49
USDT 1.00
SBD 2.61