Thank you @hypexals-spiral
The answer is not written in the script like for example "and this is why Margo ....."
So it is open to interpretation even for me. Here's what I think happen. Dr. Sabrozi had a legitimate but secretive research lab. Margo was his assistant or a patient possibly. She managed to take control of his mind and keep him captive (we never specified the duration of his captivity). then she go mental and she became corrupted with power (Paul or father and Son murder scene come to mind) Remember also a scene where she ask for "password to continue with my work" I think there is a clue there... Anyway why those directors have to be so cryptic???
Those questions you ask are all legit, because I have ponder them as well.
Glad you enjoyed the ride we were happy to show our JUJU to you. I wish I have more episode ready to go right now but they are super hard to do..
Cheers!!