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RE: The Forest - Wilderness, Requiem, Laboratory? How Cellulose Is Reinvented

in #steemstem • 7 years ago

I have a question
As you said these hydrogels are biocompatible and of course being a biopolymer it should most likely be biocompatible. But at the time of preparation of these hydrogels, one must reach the pH of around 13 to dissolve these cellulose fibres and with this basic pH, it will never be biocompatible. People have tried by either washing the hydrogels with water to remove the excess base or they have used urea or NMMO. But again using such chemicals to lower the ph to neutral is not beneficial for the cells.
What's your opinion on this? how these different cellulose (NFC, MFC, CNF) can be used for cell study. So, not have any biocompatibility issue.

7 years ago in #steemstem by
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     7 years ago 

    Hey @vinamra. Thank you for your question! I did not say that hydrogels are biocompatible, but nano-cellulose is.

    Moreover, CNCs have proven excellent biodegradability (cellulose nanoparticles were found to degrade faster than their macroscopic counterpart)(31) and have low ecotoxicological risk.(32) From a toxicological point of view, cellulose-based materials have been generally showing excellent biocompatibility on a bulk basis(33, 34) and, CNCs in particular, exhibit low cytotoxicity to a range of animal and human cell types.(32, 35-39) Although some studies have recently suggested that cytotoxic responses can occur at high CNCs concentration,(40, 41) those are still significantly lower than the ones found for other nanofibers such as multiwalled carbon nanotubes and crocidolite asbestos,(41) providing the impetus for their use in bioapplications.

    Cited from this source. I hope this answers your question.
    Cheers!

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