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RE: Brewing without Hops: Genetically engineering yeast to make hoppy flavor
I agree, for a microbe to replicate the flavor profile of a species in an entirely different Kingdom is pretty far fetched.
Using CRISPR, or any genetic engineering method to create an improved hop strain is a great idea. It'll certainly be a challenge with anti GMO sentiments that currently pervade, but it'd be a great use of genetic engineering to solve an agricultural issue.