Chinese Pseudoscience #1: Acupuncture 针刺 - Part 2: Research

in #steemstem6 years ago (edited)

In part 1, we looked at the very questionable history the Acupuncture attempts to portray. In short, it's not that the Chinese were stupid and practiced fake things (not any more than any other country, anyway) - The evidence shows they knew acupuncture was nonsense many hundreds of years ago to the point of banning it. It was only resurrected to appease the 'peasants' in the 1950's by Mao Zedong (who didn't even believe it himself), because there simply wasn't enough western medicine and doctors available.

But apparently that's not enough to dissuade the world, who embraced the propaganda in a kind of frenzy to be a part of some mystical, oriental culture in a far away land.

And ever since, it's just kind of survived skepticism.

But let's put our skeptic hats on, whether you're a passive reader or somebody whose entire career is dependent on acupuncture, and dig into the research.

Meta-analysis

Meta analysis is the statistical results of numerous studies, in an attempt to improve reliability over individual trials. In science, trials that are done by one small team, tested on 12 healthy women in one location is far less reliable and far more open to manipulation than 20 trials covering 30,000 individuals from all over (obviously, depending on the nature of the research context).

Typically, Acupuncture research vomited out into the mainstream media comes from individual studies that suddenly report a significance in data, and they get all the attention. Because positive results are far more interesting than negative.

But if God appeared once, to one person, I'm not about to get on my knees and pray on that assumption. Likewise, if one town in Siberia tell me Gold is nutritious when shoved up my arse, I'm not going to start raiding the national bank.

So with meta-analysis in mind:

Qi

Qi or chi — pronounced "chee" — is the energy flow created along the pathways that connect the acupuncture points on the body.

Between each qi point is connected by a path called a meridian. Basically by messing around with these pathways and points, you can in theory solve an absurdly wide range of medical issues including but not limited to:

Allergies, Asthma, Sinusitis, Headaches, TMJ, Back Pain, Sciatica, Musculoskeletal Problems, Insomnia, Anxiety, Dizziness, Depression, High Blood Pressure, Chronic Fatigue, Fibromyalgia, Addictions, Indigestion, Constipation, Sexual Dysfunction, Post-Operative Recovery, Palliative Care. Menstrual Irregularities, Menopause, Conception Difficulties, Pregnancy, Childbirth, Lactation Difficulties, Postpartum, Ovarian and Uterine Problems, Prostate, Infertility, Impotence, Cough, Digestive Problems, Behavioral Problems, Ear Infections, Sleep Problems, Prevention, Stress Management, Wellness, Seasonal Attunement, Muscle, Bone and Nerve Pain and Diseases Sprains / Strains Back Pain Leg Pain Foot Pain Stiff Shoulders and Neck Lumbago Sciatica Tennis Elbow Carpal Tunnel syndrome and Painful Joints TMJ; Toothache Headache and Migraines Rheumatism; Arthritis Facial Paralysis; Bell’s Palsy Fibromyalgia

And all it takes is a few needles in the right spots!

But seriously let's look into that.

Toothpicks

Numerous studies have looked into the specific qi points around the body. There's no medical reason to believe they exist, they just do, apparently. To test this, over 600 adults were put into a randomize trial with four methods of treatment; individualized acupuncture, standardized acupuncture, simulated acupuncture, or usual care.

Simulated acupuncture was the most interesting to me. They used toothpicks. To be clear, they lightly stabbed the patients with toothpicks - in random places, not in any known 'qi' spots - and then pulled it away carefully without breaking the skin.

The results may surprise you.

toothpick-289163_1280.jpg

There was no statistical difference between Individualised and Standardised acupuncture, and there was no difference between those and the toothpick puncture. But here's where it gets hairy. Those in the three acupuncture groups reported better results than those in the fourth group 'usual care'! How can this be?

The problem lies in the flawed study itself. The patients were not entirely blinded in this study. Usual care knew they were 'not getting acupuncture' and obviously the acupuncture patients new that they were. Not only this, but there was no restrictions; those three groups were allowed to continue taking 'usual care' medication painkillers and the like as usual.

This means not only is the study worthless to compare real and TCM treatment, but it couldn't even result in a statistical difference between sham and 'true' acupuncture anyway! Toothpicks are just as valid a placebo as expensive alternative medicine.

Nonetheless, this was hailed as a win for acupuncture, with the author focusing on how both sham and real treatments are still superior to usual care. Mainstream media sucked this up and, well, the rest is history.

Osteoarthritis

In another study of almost 300 people over 12 months, 'real', and 'minimal' acupuncture, as well as no treatment was trialed for osteoarthritis, because the medication for this is known to have severe side effects with some known fatalities. A safer alternative was in demand.

What they found in this non-blinded study was that there was a statistically significant improvement between having either real or minimal acupuncture, and having nothing at all. But the difference between real and minimal was negligible. Not only this, but the statistical significance vanished over the extended period of time of the study.

Hmm, I wonder why. Could it be... placebo?

Back to Meta

Now, these are just a couple of examples of how results can and are misinterpreted. But in the larger scheme, over 3,000 trials have been tested on acupuncture, and the outcome is simple: There is no statistically significant difference between getting acupuncture, getting toothpicks, or getting a pat on the back 3 times a week.

So where do acupuncture apologists get their data from? Simply, they either cherry pick the few individual studies, or they manipulate the conclusion of results. Here's what I mean.

In one meta-analysis for the treatment of vomiting and nausea, they concluded that the 24 studies:

failed to show a significant benefit using nonpharmacologic techniques.

Furthermore when analysing the results, they point out:

Of the 24 studies identified, 5 were excluded because of inadequate randomization (36,37), inadequate blinding and a quality of study score of 0 (38), poor study design and inadequate reporting of results.

All it takes to proclaim success is to dig up one of those disqualified studies and send it to the press for publishing, despite the clear and large flaws in their design.

A more specific example. In a meta-analysis of 13 trials (including one above), there was indeed a notable difference between real and fake acupuncture treatment, and even more difference between those and no acupuncture. But this difference was 10 points on a 100-point scale, 10 points being 'practically indistinguishable to patients'. It would be the equivalent of taking 1/10th of a painkiller for your headache. Oh, and it was once again, not a blind set of trials.

One particular outrageous outcome was from a meta analysis of almost 20,000 patients. It found exactly the same results as above, and another, even larger study which found nothing significant were both celebrated as successes once an author cherry-picked a few insignificant, positive results from the many thousands.

When research is published, it has gone through dozens of hours, weeks of time and thousands of dollars. When that research hits the media, it goes through a couple of minutes reading the concluding paragraph. Every party, from the researchers to the patients and the media wants a positive result. So of course they're going to find it.



The dishonesty is appalling.

So why do we need so many studies?

We don't. There are calls to stop researching now because as far as science is concerned, acupuncture is dead as a dodo. But the problem is, like all alternative medicine, is just how broad it is, covering such a wide range of ailments. This forces researchers to try and test for each and every individual ailment, each one taking thousands of people, money and time.

Realistically it would be impossible to cover every claim, and even if they succeeded, acupuncturists could easily just add a few more, and the debate goes on. So although we don't need more research, there will likely be more, and the only ones that will seem the limelight are the few that say some vague positive spin on their results, regardless of how trivial.

What other medicine do we put through 3,000 trials including millions of patients, find no significant proof that it actually does anything, and then give it a multi-million dollar industry worldwide to play with anyway, along with this cultural backlash and protection that acupuncture enjoys?

Think about that.

For those who have perhaps had acupuncture and swear by it, or its your job, or your belief or whatever, you need to think about this scientifically. If I can't walk and I wheelchair myself off a 7 story building, only to find I wake up in hospital with the ability to walk again, would it be wise of me to go around telling eveybody to jump off buildings?

Or should I look at the 99.999% of other incidents where instead, the person's leg bones shoot through their rib cages and into their ears? Perhaps what you are experiencing is something else, say, placebo.

Placebo

There is no shame in benefiting from placebo, the psychological effects from believing something is treating you are very real, and if you haven't been scammed into it, there's no issue. But it should be carefully and conservatively used as a doctor's tool, not manipulated for a multi-billion dollars industry of scams.

Next time you read a study saying acupuncture works, take a step back, a deep breath, and read the other 3,000.

My next post in this Chinese series will address another big popular one, cupping therapy. Athletics swear by it! Urgh.

WhYkkh9.gif

Image Sources CC0 or acquired with permission

Sources:

Osteoarthritis (paywall)
Qi nonsense
Acupuncture treats none of these
Toothpicks
Vomit Study

Sort:  

The problem with bias towards positive results seems to be a pretty serious problem, especially in the sciences studying people where finding good sample sizes and properly controlling experiments is quite hard.

if one town in Siberia tell me Gold is nutritious when shoved up my arse, I'm not going to start raiding the national bank.

If you know you can get away with it, you should go for it regardless... :P

You know you're totally right. Brb, going to prison

If you can post from there, you can make a photography post series for your tattoos. :D

ahaha! All this needle talk i'll be glad to never see one again!

Hahaha! The needle connection was totally lost on me here :P

What other medicine do we put through 3,000 trials including millions of patients, find no significant proof that it actually does anything, and then give it a multi-million dollar industry worldwide to play with anyway, along with this cultural backlash and protection that acupuncture enjoys?

Chiropractic and homeopathic medicines spring to mind. We (the human race) have an almost infinite appetite for bulls$@t :/

We do! It's just easier that way! Why bother struggling with truth when you can chill with lies?

From my personal perspective, most TCM is medically effective, but unfortunately cannot be proved by current scientific method. The most commonly used RCT method is not applicable for Chinese medicine. If you ever tried TCM and know how it works, you understand why. Acupuncture and Chinese medicine have the same principal. The Real World Research (RWR) or something similar might be a good option, but still developing. In a word, failure in scientific tests doesn't mean TCM's efficacy is pseudo-science; it may not be science at all. The word 'scientific' is not equal to 'correct', and there is a much bigger world outside of science.

Acupuncture has cured millions of people for more than 2,000 years, so if you are logical you should understand that your pseudo meta-analyse has a very small weight against these facts.
The core principle of acupuncture is that 1 doctor is performing one individual diagnostic for 1 individual patient. So If you enter thousands of wrong diagnostics into your analyse, you get statistical noise. Now about placebo effect, if western medicine cannot explain placebo effect, there must have something that this science don't understand. How does the brain work ?
https://aeon.co/essays/your-brain-does-not-process-information-and-it-is-not-a-computer
Nobody knows.
When you bring a drop of water on a seed, the seed germinates. You can think this is a chemical process only, but I think that there is an energy that will organize a plant from a seed : the QI.

Nobody said Placebo isn't understood, it's very well understood. It's not perfectly understood, but then neither are the mechanics of how a bicycle works. There's nothing mystical about placebo.

And regarding everything else you said:

“That which can be asserted without evidence, can be dismissed without evidence.” - Hitchens

People spend thousands of dollars to get "educated" in this quackery. So infuriating.

So your point is people are stupid?

No. My point is that people are being defrauded.

Well my point is that people are stupid!

We are indeed :) I know I am certainly, that's why we need to spend some time educating ourselves instead of believing quacks and relying on our "great" intuitions ;) And that's why I love these posts :) They are stupidity mitigation...

Good that you distinguished the difference between saying 'people' and 'they'. I certainly include myself and you in that =P The only difference is we are aware and doing whatever we can to improve. Good life habit

I thought it was the same 😂😂😂

There is no shame in benefiting from placebo, the psychological effects from believing something is treating you are very real, and if you haven't been scammed into it, there's no issue.

You steal the comment i was about to make. The placebo effect is the only good in it, IMO.

I will now buy a bunch of toothpicks to cure my headache :D

  • Experimental evidence of therapeutic efficacy reported by the text "15 cases of headache treated with the Tou Tong Qi Xue (curious point treating headache)" by ZHANG Chang Xi Service (Department of Chinese Medicine and acupuncture-moxibustion of the Ling Wu City People's Hospital, Ning Xia Autonomous Region 宁夏 灵武 市 人民 医院医院 医医

Reading the text "15 cases of headaches treated by Tou Tong Qi Xue" JIAO Jun Jie (author of the previous article) has allowed the author of this article to make a great profit. Thus, from April 2002 to March 2003, he used the point in question to treat with good results many types of headache (neuralgia of the great occipital nerve, tension headache on one side, headache accompanied by confused spirit and feeling of distention caused by cervicarthrosis, trigeminal neuralgia):

Healing (complete disappearance of pain after 1 to 6 sessions, no relapse at 2 months): 17 cases (58.6%).
High efficiency (net decrease of pain after 3 to 6 sessions, no aggravation at 1 month): 9 cases (31%).
Without effectiveness (noticeable decrease in pain after 6 sessions or disappearance of pain but relapses occurring quickly): 3 cases.
The overall efficiency rate is 89.7%.
He also discovered that this point provides sensational efficiency against insomnia and loss of consciousness.

Source :
https://institut-yin-yang.com/produit/a-t-c-recueil-n-43/

Lol, you have to be one of the funniest commenters I have!

Well.... I am what I am... yesterday was a full-moon night. This explains things :D

So you are... A werewolf?

More precisely, a vampire-werewolf :)

I think the judgement over the legitimacy of acupuncture largely depends on your definition and understanding of the Chi.
While the entire spiritual point of view is probably rather non-scientific, a more practical approach to the concept does reveal a deeper comprehension of human anatomy.

Not coincidentally does the Chi emerge in various representations in traditional martial arts because this is where you need (self-) awareness and control of the human body to perfect your style.
In a similar sense (non-esoteric) acupuncture is a completely justified traditional representation of practical anatomy, even if the claim of it being able to cure everything is of course nonsense.

tl,dr: Acupuncture and Chi are partial nonsense, but represent a naive/archaic understanding of human anatomy

I find all of this highly unlikely, but I'd be open to reading where you're getting this information from.

As far as I've learnt over my life, Qi can be used little more than a philosophy or meditative ideology perhaps.

I spent a few minutes on google and the best I found was this

It talks about how there has been scientific proof that these meridian pathways exist (that connect qi points), but looking at their source seems to be a very biased acupuncture website.

Checking their reference at the bottom takes me to 'X-ray phase-contrast CT imaging of the acupoints based on synchrotron radiation' Which I accessed on scihub, and without digging deeply into it:

'These samples were takenfrom adult white New Zealand rabbits.'

So it's another example there of misleading the public by saying scientists have proved meridians for acupuncture when really all they did is scan some rabbits.

I mean this is only one study, making it easy to pick apart, but that's the thing, all the 'proof' of these things that anybody can ever find are individual studies, which are further debunked by dozens or hundreds of others. If you can provide better, please do!

Well I am not even arguing on the level of statistical significance of (meta)studies or discussing whether bioelectromagnetism is a thing, just speculating how the whole concept could have emerged historically. Your source does look interesting though.
Judging from modern anatomy that it is safe to assume that particularly sensitive regions of the body like vertices of the nervous or viceral system exist (solar plex, the temples, etc.). As the display an evident high responsiveness to external stimuli (for instance a precise hit to the solar plex will most likely lead to some temporary incapacitation and is really not that pleasant), their significance has been known to both martial artists and medical practioners in the eastern hemisphere for a long time and people started to research this with the means available to them. While this is no strict evidence I also know from experience that e.g. masters of Ju-Jitsu, Kung Fu etc. do have a good intuitive understanding of orthopedy, being able to infer potential problems of joints just by studying your posture.
Whether you can actually derive a therapeutical approach from that was not really decidable for our pedecessors, just as our medical knowledge in medieval Europe was also quite limited, because they had no systematic medical research. So while there is a large esoteric framework surrounding acupuncture I would argue its origins are not necessarily pseudo-scientific, but rather contemporarily scientific.

Well its origins are discussed in part 1 which you should read if you haven't, since historically, even China dismissed it as rubbish and all the scholars they had pointed out that it didn't work hundreds of years ago.

Any success we've had with it since Mao used it for political gain has been entirely circumstantial. I can't say to understand martial arts to any degree but I can guarantee their intuitive ability to understand problems of posture comes from years of experience and knowledge of the physical body and its sensitive spots in general, rather than being spiritually connected with qi spots and meridian pathways.

If there's no evidence of these things, and any claim to use them to our benefit is proven false time and time again, or there is some slight benefit that is circumstantial with better results coming from alternative methods and even sham acupuncture, I don't see any reason to keep it alive. The fact that the effects can be replicated without even using the qi locations is one of the bigger nails in its coffin.

I'm still a little confused on what your stance on it is, to be honest, but the research has to be considered with these things no matter what one's position may be

gracias por la ayuda =) buena publicación

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"Acupuncture" is known to cause a release of adenosine:

https://www.nature.com/articles/nn.2562

However this rant is pretty convincing that sticking a needle anywhere does do that meaning that the specifics of acupuncture are irrelevant.

https://sciencebasedmedicine.org/another-overhyped-acupuncture-study-misinterpreted/

It is likely that getting poked with needed does something beyond placebo. However that something, probably isn't very much. And has nothing to do with the specific needling spots of acupuncture.

In all, a well written post about a junk health treatment.

Oh so you DO read my stuff! haha

The first study you cited is on mice, so let's not take that too seriously when it comes to discussing how much pain they were in 'as revealed by how quickly they recoiled from heat and touch' - after being injected with extra-heat-touch sensitivity drugs.

Additionally: 'when adenosine was turned on in mouse tissue by other mechanisms, the pain response was equal to or better than the response generated by acupuncture.' You could just pinch somebody and get the same results. Acupuncture having any effect there is purely circumstantial, in the same way that it might relieve somebody's itchy back or burst a big spot.

That being said, yes there are some individual studies that show something - regarding the stabbing of skin rather than actual acupuncture, but again the differences are barely clinically significant, as mentioned, around 10 points on a 100 point scale in most cases, or as mentioned, simpler and cheaper alternative methods often prove superior.

I read everyone's stuff some of the time. ;) I don't comment often. It's just a time constraint thing.

I wouldn't worry about the mouses pain response, only that adenosine was released. That's the interesting observation. The activation of the A3 adenosine receptor is thought to be involved in the human pain response as well (there are a variety of publications discussing this).

At this point I think the more interesting avenue of study is the stimulation of that adenosine pathway. Acupuncture is largely forgettable.

Yep, if it can replace the opioid as a leading pain relief then nothing but goodness has come from those little critters!

Time, and a significant amount of research will tell if those dreams can come true.

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