RE: Engineering Human B Cells With CRISPR
As human beings, we have developed sophisticated immune systems that allow our bodies to fight against viral infections that harm us. Surprisingly, bacteria - despite being unicellular organisms - often possess a similar adaptive immunity, called CRISPR-Cas systems. But these CRISPR-Cas systems of bacteria have a very different function to that of our immune system
One of the least understood aspects of the CRISPR-Cas systems of bacteria is how these microorganisms control their activity, since an excess of this can result in an autoimmune disease, and a shortage of activity could allow the viruses to destroy entire bacterial communities. The team's research shows that by communicating openly with each other, the bacteria reach the right balance between the two results. Greetings, you are very good job in this publication I am the subject
forgive my English written is not very fast and I made a mistake without wanting to transcribe my comment, I think it is not reason to mock, with all respect, is not the spirit of this community, a thousand apologies and that you are very well
Have some fun, live a little :)
Oh no? My sarcasm is what it is.
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Not sure what you mean here.
The bacteria have a very good ability to not recognize "self" nucleic acids and incorporate them into the CRISPR Array. Though indeed the mechanism is not well understood. In fact one of the least well understood aspects of CRISPR relative to the bacterial immune system itself is the acquisition phase by Cas1 and Cas2.
Nevertheless, the focus of this blog was on the application of CRISPR editing in human B Cells. My initial description of CRISPR was just to get people on the same page, and make a joke about the use of one adaptive immune system to make modifications to another entirely separate adaptive immune system. :)