Sorry this is impacting you so hard. I'm sure those that figure out how to adapt to these changes are going to come out on top. Used to do SEO work on my own websites and each time Google did massive changes you would see everyone getting depressed that it was the end of their business. Short term it was horrible, but once you adjusted your techniques with some trial and error those that adapted always benefited as less people knew the secrete sauce to being on top.

I know nothing about twitter as it's a platform so can't lend any sort of useful help other then to say someone that can make the major life changes you made and stick with it should be able to weather this new obstacle and figure out how to adjust your business model to achieve your long term goals. Sometimes we are forced to take 2 steps backwards to go one forward and that is ok as long as you are focused on where you are going.

This is a setback and it's painful, but don't let it be more then that.