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RE: NSAIDs Like Ibuprofen May Significantly Increase Your Chance Of A Heart Attack
Thank you for the informative reply. I always learn something from our interactions. Didn't know about viox, wonder what the true cause of the heart issues is. Perhaps there is more tissue specificity to some of these compounds then others?
Yeah I know about paracetamol and cox-2 inhibition in the central nervous system. It's fascinating to me how these compounds are so different in their effect but the target is the same.
Good thinking. They are really interesting drugs but as a chemist you may be able to postulate better theories on why based on the structure of the compounds! I'll leave that to you haha. Tylenol basically becomes inactivated. As far as the heart stuff, we really are all over the place. Obviously, we are not understanding it well enough or certain drugs are causing heart issues not from the COX-inhibition. Perhaps the 14% increase with Aleve was true effects from COX-inhibition...but Vioxx DOUBLING cardiovascular mortality....now something else has to be going on there haha.