Vitamin D still "works" even if you're not taking magnesium supplements

in #science7 years ago (edited)

Role of Magnesium in Vitamin D Activation and Function (Uwitonze and Razzaque, 2018)

Tl;dr: magnesium (Mg) is a cofactor for tons of enzymes, a few of which are involved in the conversion of cholecalciferol into 1,25-(OH)2-vitamin D3 (active vitamin D) or 24,25-(OH)2-vitamin D3 (inactive vitamin D).

Highlights from the study: 1) sunshine is the best source of vitamin D QED

Mg is the 4th most abundant mineral in the human body after calcium, potassium, and sodium.

Most Mg is in bone and teeth.

Foods high in Mg: almonds, bananas, beans, broccoli, brown rice, cashews, egg yolk, fish, flaxseed, green vege, milk, 'shrooms, nuts, oatmeal, pumpkin, sesame seeds, soybeans, sunfower seeds, corn, tofu, grainz.

Admittedly pretty awesome Figure:

Most interesting line: "Mg deficiency results in reduced 1,25-(OH)2-D3 ... and has been implicated in Mg-dependent vitamin D-resistant rickets."

If there actually is: 1) vitamin D-resistant rickets; and 2) Mg actually fixes it; then 3) WOW interesting mayhaps I stand corrected.

I stand corrected.

Vitamin D resistance in magnesium deficiency: https://www.ncbi.nlm.nih.gov/pubmed/941867

Vitamin D-resistant rickets due to magnesium deficiency: https://link.springer.com/chapter/10.1007/978-94-009-4131-1_28

But too much magnesium caused pseudo-rickets in this case: https://www.sciencedirect.com/science/article/pii/S0022347688805869

further reading: Vitamin D, Fiat Lux, and Circadian Rhythms & Sunlight and the circadian rhythms in your skin.

That's all for now!

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Wow! Thanks for the info! I just wish we had more sunshine!

Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status? https://www.ncbi.nlm.nih.gov/pubmed/26773013

Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy.
https://www.ncbi.nlm.nih.gov/pubmed/21155624

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