I don't know Systemics, but war and famine came to mind. What might be out of order in better times becomes "normal" in other times. However, I think we need to look at the brain, at circuitry, for the source of some mental disease. Because I do believe there is mental disease, where people suffer. There may be inflammation or trauma, or any other reason. The disease could be treated if we understood the physical basis. I have a brother who suffered a bout of autoimmune encephalitis. At first it seemed he had dementia, then blood tests revealed physical abnormalities and treatment (mostly immune suppressants) stopped the inflammation. Not soon enough to prevent all damage, but at least the treatment brought him back. I think that is an example of how understanding the physiology of brain disease (that's how I see mental illness) will help to alleviate suffering. For me, that is the point of all medicine.
Thank you for your kind words. It did take many hours. I usually approach subjects I'd like to learn about. I keep reading and then write. It's not an efficient way to proceed, but I learn a lot :)