Hi @suesa.

I was specially interested on what you said about leptin. We know it is produced on fat cells/tissues. The thing is if we could get resistant to it somehow, just like what happens with insulin?
I imagine that if we get fatter and fatter, leptin rises and stays high. Therefore the receptors on the hypothalamus might get desensitized due to the always high leptin levels. As a result it can’t account for our internal clock and things keep getting worse. That’s probably why obesity is also super bad.

Thanks for this post.