RE: Experimental Hair (Loss-Fighting) Gel
...and it seems that I've fallen down a rabbit hole, here:
https://www.nicehair.org/reduce-pgd2-scalp/
In 2012, the University of Pennsylvania published a breakthrough study concluding that PGD2 was found in higher levels than normal in the scalps of balding men. It seems that PGD2 prevents the hair follicles from maturing.
A study has analyzed the 289 constituents of 12 selected herbs to see whether they would work as PDG2 inhibitors. The properties were analyzed for skin permeability, sensitization, irritation, corrosion, mutagenicity, tumorigenicity and reproductive effects. Although many were found to have PGD2 inhibition, many caused adverse reaction and also poor skin permeability. Among them, ricinoleic acid, acteorside, amentoflavone, quercetin and hinokiflavone were good inhibitors with minimal adverse skin reactions (Fong et al., 2015) and may be safe and efficient for hair loss treatments. But, without further studies regarding their efficacy in hair loss treatment or at least new research confirming their effect on PGD2, some of the inhibitors presented above remain a mystery.
Studies suggest that some flavonoids such as quercetin could be used effectively as topical medication rather than supplements, so that people experiencing hair loss could benefit from an increased effect. When it comes to skin conditions quercetin is efficient in inflammatory skin diseases (Caddeo et al., 2014) as well as to control UVB-mediated oxidative damage of the skin (Casagrande et al.,), so topical application of these flavonoids might be more efficient than using them as dietary supplements. In alopecia areata, subcutaneous injections showed induced hair regrowth in preexisting alopecic lesions (in mice).
And, here, many years later, the results seem to suggest:
http://regrow-hair-loss.blogspot.com/2017/04/a-breakthrough-for-hair-loss-pgd2-and.html
In 2012, researchers discovered that increases prostaglandin D2 (PGD2) expression reduces hair lengthening. The researchers hypothesized that a PGD2 inhibitor might halt hair loss and even regrow hair.
Unfortunately, we haven't heard much from the PGD2-inhibitor human trials. On top of that, hair loss forum trials with PGD2 blockers did little more than halt hair loss.
However, some hair loss experimenters are documenting regrowth by both blocking PGD2 and increasing PGE2 expression. The net – if we're going to try a prostaglandin protocol and we want to maximize our chances for hair regrowth, we need to both decrease PGD2 and increase PGE2.
Fortunately, we can decrease PGD2 and increase PGE2 naturally. Restricting omega 6 fatty acid consumption may decrease PGD2 expression throughout our bodies, and getting UVB radiation (from the sun) can increase PGE2.
So that's a PGD2 inhibitor and a PGE2 promoter to help re-grow hair, for those keeping track.
The following link goes a bit more into it:
https://www.nicehair.org/increase-scalp-pge2-decrease-pgd2-cure-hair-loss/
...and...
If you've followed to this point, the addition of a PGD2 inhibitor like Quercetin (powder) and PGE2 promoter like Ginger Root could prove to be beneficial for my formula.
The addition of sperm is to be left to your discretion. I suppose it's for the more desperate, or perhaps "brave" of the bunch out there.
As to whether or not I give it a go, well, I wouldn't admit that I jizz on my own head even if I did, so what's the point of even saying that I won't? Take that however you wish...
...moving along...
Here's an argument for Quercetin being a good choice as the PGD2 inhibitor:
...and still more digging reveals...
http://hair-growth-remedies.com/using-wheat-germ-oil-for-hair-growth/
https://food.ndtv.com/food-drinks/6-incredible-benefits-of-wheat-germ-oil-1638519