You are viewing a single comment's thread from:

RE: Experimental Hair (Loss-Fighting) Gel

in #life • 5 years ago

More relevant information can be found here:

http://stemcellbaldnesscures.com/tag/cytokines/

A major part of the wound healing cascade is the release of growth factors and cytokines from stem cells into the layers of the scalp at the site of the wound. These growth factors and cytokines function like a light switch, turning on lost or decreased function of the hair follicle.

Sperm contains cytokines - stem-cells for hair follicles!

5 years ago in #life by
$0.00
    Reply 4
    Sort:  
  • Trending
    • [-]
     5 years ago (edited)

    ...and it seems that I've fallen down a rabbit hole, here:

    https://www.nicehair.org/reduce-pgd2-scalp/

    In 2012, the University of Pennsylvania published a breakthrough study concluding that PGD2 was found in higher levels than normal in the scalps of balding men. It seems that PGD2 prevents the hair follicles from maturing.

    A study has analyzed the 289 constituents of 12 selected herbs to see whether they would work as PDG2 inhibitors. The properties were analyzed for skin permeability, sensitization, irritation, corrosion, mutagenicity, tumorigenicity and reproductive effects. Although many were found to have PGD2 inhibition, many caused adverse reaction and also poor skin permeability. Among them, ricinoleic acid, acteorside, amentoflavone, quercetin and hinokiflavone were good inhibitors with minimal adverse skin reactions (Fong et al., 2015) and may be safe and efficient for hair loss treatments. But, without further studies regarding their efficacy in hair loss treatment or at least new research confirming their effect on PGD2, some of the inhibitors presented above remain a mystery.

    Studies suggest that some flavonoids such as quercetin could be used effectively as topical medication rather than supplements, so that people experiencing hair loss could benefit from an increased effect. When it comes to skin conditions quercetin is efficient in inflammatory skin diseases (Caddeo et al., 2014) as well as to control UVB-mediated oxidative damage of the skin (Casagrande et al.,), so topical application of these flavonoids might be more efficient than using them as dietary supplements. In alopecia areata, subcutaneous injections showed induced hair regrowth in preexisting alopecic lesions (in mice).

    And, here, many years later, the results seem to suggest:

    http://regrow-hair-loss.blogspot.com/2017/04/a-breakthrough-for-hair-loss-pgd2-and.html

    In 2012, researchers discovered that increases prostaglandin D2 (PGD2) expression reduces hair lengthening. The researchers hypothesized that a PGD2 inhibitor might halt hair loss and even regrow hair.

    Unfortunately, we haven't heard much from the PGD2-inhibitor human trials. On top of that, hair loss forum trials with PGD2 blockers did little more than halt hair loss.

    However, some hair loss experimenters are documenting regrowth by both blocking PGD2 and increasing PGE2 expression. The net – if we're going to try a prostaglandin protocol and we want to maximize our chances for hair regrowth, we need to both decrease PGD2 and increase PGE2.

    Fortunately, we can decrease PGD2 and increase PGE2 naturally. Restricting omega 6 fatty acid consumption may decrease PGD2 expression throughout our bodies, and getting UVB radiation (from the sun) can increase PGE2.

    $0.00
      Reply
      [-]
       5 years ago (edited)

      So that's a PGD2 inhibitor and a PGE2 promoter to help re-grow hair, for those keeping track.

      The following link goes a bit more into it:

      https://www.nicehair.org/increase-scalp-pge2-decrease-pgd2-cure-hair-loss/

      Ginger is a herbaceous perennial plant, which is a common ingredient in Asian cuisine. Ginger root has been a traditional Asian remedy for hair loss, and even though its effects on the human scalp haven’t been properly researched its potential to increase PGE2 has been shown in studies. Research shows that the plant has an anti-inflammatory effect and increases PGE2 (Shivanad, 2005) (Joland 2004).

      ...and...

      Castor oil is a vegetable oil that is obtained by pressing the seeds of the Ricinus communis plant. It’s used as traditional medicine for a number of ailments including baldness with self-reporting cases all over the internet showing its effects. The mechanism behind hair loss might be its ability to increase PGE2 as research has shown. Studies on pregnant rats have shown that feeding them castor oil increases PGE2 synthesis. (Gao et al., 1999) (Tunaru et al.,2012 ) Although it hasn’t been studied as an actual treatment castor oil has been used topically for years without any side effects so giving it a try wouldn’t do any harm.

      $0.00
        Reply
        [-]
         5 years ago (edited)

        If you've followed to this point, the addition of a PGD2 inhibitor like Quercetin (powder) and PGE2 promoter like Ginger Root could prove to be beneficial for my formula.

        The addition of sperm is to be left to your discretion. I suppose it's for the more desperate, or perhaps "brave" of the bunch out there.

        As to whether or not I give it a go, well, I wouldn't admit that I jizz on my own head even if I did, so what's the point of even saying that I won't? Take that however you wish...

        ...moving along...

        Here's an argument for Quercetin being a good choice as the PGD2 inhibitor:

        Studies suggest that some flavonoids such as quercetin could be used effectively as topical medication rather than supplements, so that people experiencing hair loss could benefit from an increased effect. When it comes to skin conditions quercetin is efficient in inflammatory skin diseases (Caddeo et al., 2014) as well as to control UVB-mediated oxidative damage of the skin (Casagrande et al.,), so topical application of these flavonoids might be more efficient than using them as dietary supplements. In alopecia areata, subcutaneous injections showed induced hair regrowth in preexisting alopecic lesions (in mice). (Wikramanayake et al., 2012)

        $0.00
          Reply
          [-]
           5 years ago (edited)

          ...and still more digging reveals...

          http://hair-growth-remedies.com/using-wheat-germ-oil-for-hair-growth/

          Wheat germ oil contains fatty acid that are longer than that of found in other hair oils like coconut oil. And that is the reason that it nourishes and conditions the hair better than all other oils. Its moisturizing and conditioning properties make it capable of repairing the damaged hair at faster rate and prevent from further hair loss.

          The vitamin B found in wheat germ oil promote the new growth and formation of new tissues, thus it helps to promote new hair growth both in terms of length and the volume of the hair. The key to healthy hair growth is the healthy scalp and healthy root of the hair which is done by the use of what germ oil.

          https://food.ndtv.com/food-drinks/6-incredible-benefits-of-wheat-germ-oil-1638519

          Wheat germ oil is a useful ingredient for maintaining healthy hair. "It is rich in linoleic acid and acts as a hair nourisher. Use it in the ratio 10:1 with other carrier oils such as olive and sesame (10 parts carrier oil and 1 part wheat germ oil) and apply on the scalp. Leave it on for some time before rinsing the hair," says Dr Ashutosh Gautam, Clinical Operations and Coordination Manager at Baidyanath.

          $0.00
            Reply

            Coin Marketplace

            STEEM 0.26
            TRX 0.11
            JST 0.032
            BTC 64799.61
            ETH 3102.94
            USDT 1.00
            SBD 3.83