Pokeweed is one of my favorite medicinal plants.
I collect young leaves and boil them 3 times for 5 minutes each time (changing water each time). Then they can be eaten like spinach with a bit of butter and spices. I like to mix them with my scrambled eggs.
I swallow up to 3 ripe berries a day for up to 4 days a week, for relief from joint pain. Do not bite into the seeds, they are the part that is toxic, just swallow whole and the seeds will pass through your system without breaking down.. You can also make jelly from the ripe berries.
The roots can be made into a powerful pain relief tincture, just be very careful with dosages.
The stems can also be made into pickles. I don't pick leaves or stems over 12" tall. If the plants do get over that height, I let them mature to harvest the ripe berries and some of the roots.

Nutritionally, poke weed is a powerhouse: A half cup of the greens provides 35 calories (10 from fat), no cholesterol, three grams dietary fiber, and 90% of your daily need for vitamin A, 60% of vitamin C, 8% calcium, and 6% of iron. Poke weed has 8,700 IU’s of vitamin A per 100g serving.
https://thegrownetwork.com/weed-garden-pokeweed/