I think about coins as startup investments with more liquidity. If a firm is essentially at a concept phase and lacks demonstrated product-market fit, they would have a hard time raising $5 million in venture funding and should not reasonably have a coin with a $1 billion + market cap. The odds of one of these firms succeeding is likely less than 1% (prob less than 0.1%). Partnership announcements are not sufficient to demonstrate traction in my mind though a significant completed trial with a partner might be.

However, a firm with a product and clear traction, such as NEO, probably has a significantly better probability of success (maybe 8-12% as a guess) as they have derisked part of the scenario. Still significant execution risk, but could plausibly create a $1 billion + market cap.

I would only HODL the latter. If you have a hot hand, maybe you can make some coin trading the earlier stage coins but it strikes me as more pure speculation less pinned to the actual prospects.

I recommend taking taking some profits, HODLing some of the remaining capital in coins whose probability and potential payoff still seem attractive, and divest early stage coins other than a small amount of trading capital.