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I have a friend who tried it. Now she sells through a gallery and does commission work. She is not technically minded so she went with traditional. Personally I would cut out the middle people and set up my own website (maybe wordpress) to begin with and take low res images of your work (with watermarks). That is the easy part. You then have to get your name out there. Check out google adwords and write some descriptive content to go with each artwork. I built my own site a few years back and got to #2 on google worldwide. I've since shut it down (too busy and stressful). Now I write instead :) I did my own SEO too. I can give you more info if you need it.

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