In 1948, Swiss pharmacologist Peter Witt studied the effect of drugs on spiders.

In 1948, Swiss pharmacologist Peter Witt studied the effect of drugs on spiders. He conducted an experiment in which he dosed the spiders by feeding them drugged flies or by giving them a drop of a drug in water. He then photographed their webs before and after the drugs were administered. These were the results.

In 1957, researchers noted that spiders on low doses of LSD were "unaware of outside influences and concentrated on the job." Their webs showed consistent regularity. On depressants, "they 'forgot' to finish what they had started and the result was a very ineffective food gathering device."