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Here's a clue, given by Mason Currey:

Throughout this time—indeed, for the rest of his life—Darwin’s health was poor. He suffered from
stomach pains, heart palpitations, severe boils, headaches, and other symptoms; the cause of his
illness is unknown, but it seems to have been brought on by overwork during his London years, and it
was clearly exacerbated by stress.Throughout this time—indeed, for the rest of his life—Darwin’s health was poor.

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