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RE: The biochemistry of ageing

in #stemng6 years ago

Ageing as we all know is one of the world's ancient deadliest diseases.

I wouldn't call ageing diseases, I would prefer the ultimate end-game. Can you imagine if immortality is a thing how occupied this world would be? We would have to colonise another planet in order to meet the ever-increasing demand of all the immortals; I would say, in some ways, ageing is a blessing in disguise.

Explaining theories can be tricky especially for laymen or people from other disciplines so be sure to use, as much as possible, laymen's term for the benefit of other readers.

Foods such as whole grain contains fibre, carbohydrate, protein and essential fatty acid that helps in reducing cholesterol levels in the body should be consumed more.

I found this statement quite disturbing. First of all, how did all of the food classes mentioned reduce cholesterol? Second of all, why do we want to reduce cholesterol? According to research and other clinicians perspective, people who were always sick usually had a low cholesterol level compared to someone with moderate or high cholesterol. Cholesterol is an essential component of the cellular membrane.

I know people usually blame cholesterol for the formation of the atherosclerotic plaque but cholesterol was actually one of the mediators to seal the microtear in the vessel cause my inflammation. The most important thing is to reduce the inflammation then, not cholesterol.

If you are familiar with sugar and its destructive capacity, you would know diet with high carbohydrates and low fibre can increase the level of reactive oxygen species commonly seen in people with diabetes. You might want to do some reading regarding how the polyol pathway increases the substrate required to synthesize ROS.

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Concerning cholesterol, isn't some of them good and some of them bad as well. At least, this is what I vaguely remember. As a consequence, should we really try to reduce all cholesterols blindly? I don't think so :)

You are correct, there are different types of cholesterol but the low density lipoprotein (LDL) which is also referred to as bad cholesterol is what this post talks is about. The body already produces enough cholesterol required by the body daily, so increased cholesterol through diet should be reduced. The body will always produce more when needed.

Sorry for the misunderstanding caused by omittion of some terms :)

Thanks for clarifying :)

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I would prefer the ultimate end-game.

Seeing ageing as the ending is a wonderful opinion which is supported by many, also defining ageing as a disease is also an opinion accept by many as seen in this article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471741/

First of all, how did all of the food classes mentioned reduce cholesterol?

Soluble Fibre is known for binding to cholesterol and taking it out of the body. https://www.ncbi.nlm.nih.gov/m/pubmed/18937894/

Low carbohydrate diet such as whole grain as discussed above also plays a role in the reduction of cholesterol levels in the body. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530364/.

Plants protein are well-known for helping in the reduction of cholesterol as seen here https://www.ncbi.nlm.nih.gov/m/pubmed/3097105/

Omega 3 fatty acids which is an essential fatty acids helps in reducing cholesterol levels as seen here https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5691715/

Second of all, why do we want to reduce cholesterol?

Yes, cholesterol is very essential for the body because it is required for the production of hormones and other substances for proper functioning of the body. The body is capable of producing 80% the amount of cholesterol required by the body, so increasing the level of cholesterol through diet increases the risk of cardiovascular disease because, we take in both LDL and HDL. As mentioned by @lemouth , there are different types of cholesterol and the low density lipoprotein (LDL) also referred to as bad cholesterol is what i am pointing at in this post.

If you are familiar with sugar and its destructive capacity, you would know diet with high carbohydrates and low fibre can increase the level of reactive oxygen species commonly seen in people with diabetes.

This is why consuming of complex carbohydrates such as whole grain is advised as mentioned above because, they take longer time to be broken down thus preventing the easy uptake of glucose by the intestine.

Am so sorry for not giving detailed explanation as i omitted some terms. Thanks for your wonderful comment, questions and observation

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