What if only brief blockade is sufficient to treat depression for an extended period of time?

Would be the ideal scenario, but so far I don't think there is any medication available that is able to do this for depression, or any other medication that I know of working on CNS neurotransmitter in this fashion.

Temporary inhibition having "significantly" long term action is yet alien, but definitely something that deserves attention!! Would definitely save the patients of so many unnecessary side effects, not to mention long term, potentially permanent damage to the CNS and even the risk of developing tolerance or dependence. Yes, this would definitely help with the issue of tolerance or dependence developing with so many of the CNS drugs.