Well, in animal studies the caloric restriction was upto 50% of baseline intake. But you have to be careful you don't want to starve yourself. In human clinical trials the caloric restriction achieved was about 15-25% (Redman et al., 2018. Based on this study I would say cutting off calories by 15% of daily requirement should be safe. Also, it is to be noted that most of experimentally controlled diets also did take care of nutritional value of components fed to animals. And as it is seen two separate primate studies food composition is also likely to play a role, even when caloric density is maintained the same. So it's good to make sure that appropriate vitamins and micronutrients are going in, along with proper composition of micronutrients. Of course this is still developing branch of caloric restriction regime, and we will know more with time.

Posted using Partiko Android