Steemit Usernames Written In the Genetic Codes

in steemstem •  last month

Endless lines of numbers and gene symbols is all I've been looking at for the past several days.

I know, sounds waaaay more fun than it really is!!!

Of course it does, keep telling that to yourself...

gene-function-3184518_640.png
Only biology and math nerds will understand, author mcmurryjulie, CC0 1.0

Ahem. Anyways.

During all that boring fun work, I got really bored playful, because I noticed that some genes have extremely interesting names, such as SMURF1, DIABLO, POKEMON (unfortunately, they had to rename this one to ZBTB7 because The Pokémon Company did not want the bad publicity with a cancer-causing gene having their trademark name - these guys are such mood killers!), etc. An idea crossed my mind - to investigate which genes share some of our precious Steemit usernames and what is their function in human and other genomes. Ready to get bored to death have some fun?

ANGEL1 and ANGEL2

@scienceangel

I guess I should start with myself, just for the sake of breaking the ice, of course, and not because I think it's totally AWESOME that these genes are called "angels"...

TransInit.png
Initiation of protein translation in eukaryotes, author Fdardel, CC BY-SA 4.0

ANGEL1 and ANGEL2 are relatively recently discovered human homologs, belonging to the CCR4 family (carbon catabolite repression 4) with their functions still not completely elucidated. ANGEL1 protein was found to bind to eIF4E, which is a very important protein for the process of mRNA translation in eukaryotes[1]. Furthermore, it was discovered that ANGEL1 competes with eIF4G in the process of binding to eIF4E[1], and that ANGEL1-derived peptide, A1-IRS interacts with eIF4E, inhibits translation (protein synthesis) and induces fast and massive cell death in several cancer cell lines[2]. Based on their results, authors concluded that A1-IRS may be new cytotoxic peptide with potential clinical applications.

ANGEL2 protein is thought to be involved in carcinogenesis, by inducing G1 cell cycle arrest by binding to p21 mRNA and stabilizing it[3].

SCO1 and SCO2

@sco

800px-ETC_electron_transport_chain.svg.png
Electron transport chain, author LadyofHats, CC0 1.0

Cytochrome c oxidase, also called Complex IV, is located in inner mitochondrial membrane and represents last enzyme in an electron transport chain (ETC). This enzyme has a very important role in maintaining life - it converts molecular oxygen to water. During this process, an electrochemical gradient is formed through the mitochondrial membrane, which is then used for ATP production[4].

SCO1 and SCO2 genes represent copper metallochaperones involved in synthesis and maturation of cytochrome c oxidase subunit II.

Protein ALEX (GNAS complex locus)

@alexs1320, @alexdory, @alexbeyman

How many of you Alexes are there?

Anyways, good news for you guys is that this gene locus has extremely complex expression pattern, meaning that, besides giving rise to transcripts that can be expressed maternally, paternally, or biallelically, the expression can be performed from four different promoters and resulting transcripts can be derived by alternative splicing of four 5' exons!

Whatever, just ignore her, maybe she'll go away and leave us alone...

4809599673_32a9a59b47_z.jpg
Due to the lack of appropriate image here, here's a completely unrelated photo of a very amused kitten in a cup, author tochichi, CC BY-SA 2.0

One of the transcripts of this gene contains two overlapping ORF (open reading frames) and ALEX protein is encoded by one of them (XL-exon1). It was shown that functional polymorphism in XL-exon1 in two families has led to increased bleeding tendency after injuries, neurological problems and brachydactyly. These symptoms were demonstrated to result from paternally inherited insertion within the ALEX protein[5].

EGO (or EGOT)

@Egotheist

DNA_to_protein_or_ncRNA.svg.png
RNA-coding genes, author Thomas Shafee, CC BY 4.0

This is a very interesting gene, because it belongs to so-called RNA genes, meaning that it gets transcribed into non-coding RNA (ncRNA). ncRNAs are RNA molecules that don't get translated into protein products, but they exhibit their function as RNA molecules. EGO (eosinophil granule ontogeny) gene is coding for long non-coding RNA (lncRNA) which has a major role in eosinophil hematopoietic cells development in the bone marrow[6]. Moreover, it was found that low levels of EGO lncRNA are correlated with poor prognosis in breast cancer[7].

Zeste gene

@zest

Drosophila_melanogaster_-_side_(aka).jpg
Drosophila melanogaster, author
André Karwath
, CC BY-SA 2.5

This gene plays a crucial role in the development of vinegar fly (Drosophila melanogaster), which is a very important model organism in genetics. Some of the reasons why this fly is widely used in research are: it can be easily cultured in laboratory conditions, it has short generation time, high fecundity, and only four pairs of chromosomes, which facilitates genetic studies of mutants[8]. Protein product of zeste gene belongs to the group of DNA binding proteins, meaning that they regulate the activity of other genes, and Zeste protein is included in transcriptional regulation of trithorax (trxG) and Polycomb (PcG) gene groups[9].

ABI1, ABI2 and ABI3

@abigail-dantes

OSC_Microbio_03_04_actin.jpg
Actin cytoskeleton, author
CNX OpenStax
, CC BY 4.0

ABI1, ABI2 and ABI3 genes belong to ABI protein family and they're involved in actin cytoskeleton polymerization and remodeling. This function is especially pronounced during the process of T cell receptor activation, where actin polymerization plays a critical role for the fidelity and accuracy of the T cell response to antigen. In T cells, this role of ABI proteins is achieved by forming the Abi/Wave protein complex[10]. Moreover, it was discovered that ABI1 functions as oncogene in hepatocellular carcinoma and that high expression of this protein is correlated with poor prognosis in patients with this disease[11].

katE

@katerinaramm

800px-E_coli_at_10000x,_original.jpg
Escherichia coli, author
Eric Erbe
, CC0 1.0

Protein product of katE gene belongs to the enzyme class known as catalases, which functions to protect Escherichia coli from oxidative damage caused by reactive oxygen species (ROS). This enzyme performs its catalytic activity by decomposition of two molecules of hydrogen peroxide into molecular oxygen and two molecules of water[12]:

2 H2O2 = O2 + 2 H2O

The KatE enzyme (also called hydroperoxidase II, HPII) contains a cofactor, heme d, and belongs to the group of monofunctional catalases[13].


These are only gene names corresponding to some of the Steemit users I could find that make sense and that are related to the important biological processes.

If you happen to find some interesting gene that is same or similar to your username, feel free to share the fun in the comment section!

Until the next extremely boring fun post, relax and keep steemSTEM! ;)

scienceangel.png

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One of the most original posts I've ever found.

USA = United States of Alex (hush, conspiracy...)

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One of the most original posts I've ever found.

AND smart!! I am in love with this post 😍

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Thank you my dearest Abi!!! :* :* :*

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Thank you very much, really appreciate it! :)

Hah! Great idea for a post. Good thing gene nomenclature has few rules or we wouldn't have gems like Sonic Hedgehog proteins.

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Thank you very much!

Yes, I agree that introducing more strict rules in the gene nomenclature would definitely take all the fun out of it :)

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Yes C. elegans geneticists are so envious of Drosophila gene names. My favourite fly gene names are:
cheap date ( mutants have low ethanol tolerance)
Indy (for I'm not dead yet- mutants live twice as long)
roundabout (an axon guidance receptor- mutants have axon that go around in circles)
dreadlocks (another axon guidance gene- mutants have axons that clump together resembling dreadlocks) @reggaemuffin might appreciate this gene!
Tin man (mutant have no heart)
Ken and Barbie ( mutants lack external genitalia)

it converts molecular oxygen

That's just what I am doing all the time! So fitting!

A truly great idea of yours, and perfectly transcribed to a post. Resteemed.

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Thank you very much, glad you liked it! :)

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It's easy when you have that nice, fresh, Alpine air :)

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In Vienna? You're kidding me, the city is like a huge oven these days.

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Oh no, Vienna is methylating you *(melt-hylating...)

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Angels... Always complaining about the nerds...

Never knew gene names were this much interesting... I thought they were named like codes "BCYWO8424" etc.. :D

Really unique content dear..!

~ Christina

I think I probably understood roughly a 6% of your post but I Ioved the way you made a fun article from your extremely boring exciting research!
💙🥊😊⚘😁

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Haha, thank you so much @katerinaramm!

For now people can at least have some use out of my research, and if I get lucky smart enough, maybe even something useful comes out of it in the future 😎

@scienceangel this is SUCH an ingenious, fun post! Honestly, sometimes I feel I could do with a hand from an ABI2 and 3 😛

Brilliant, unique, Awesome, cool..... I can go on and on...

You ROCK @scienceangel !!!!!!

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Thank you @zest!!! :*



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I thought you were going to talk about Joe Davis' Wikipedia Apple Tree project where he is transpiling DNA of an ancient apple breed to embed the English Language wikipedia... But your post is quite funny work that really follows through. Kudos!

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No, but interesting idea though ;)

Thanks for dropping by!

Nice! I probably won't get breast cancer! That's quite reassuring. I like my tits as they are.

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Ego has tiiits,
ego has tiiits,
tralalalalala!
Ego has tiiits.

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Hahahahaha, this made my day, thank you @sco!

😂 😂 😂

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Always at your disposal ;-)

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That's your envy singing.

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No worries, even if something happens, modern medicine has a solution, I think these would be perfect for you:

hello-kitty-breast-implants.jpg

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I'm not even going to ask how you found these.

Nice one, now this is a different mention of my name.
Pretty interesting to see that so many names were chosen and that each of them does something else entirely. While usual for you, I am still awed at this and the size of the human genome and the complicated task of mapping stuff in it.
Guess its why I read your articles (and other articles) :P
I probably encouraged you the least in the past but this doesn't mean that I don't appreciate or like your articles.

Cheers!

Awesome post. From the title, I thought you were going to talk about some sort of DNA cryptographic - LOL ... fun post.

Beautiful post i appreciate your beautiful creativity thanks for sharing your beautiful blog

Wow, that's so extraordinary!!! Amazing :D

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I was looking for yours, but without success... Even tried to find dex + ter + dev, but nothing interesting came up :(

The naming reminds me of the naming of particle accelerators and related experiments 😅 HERA, FLASH, TOTEM, DAISY, just to name a few😁
I should start to write articles about such things...

Definitely a very original and fun post @scienceangel ! There wouldn't happen to be a "Love" or a "Joy" gene by any chance?

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Thank you so much @terrylovejoy! Actually I found this one:

https://www.ncbi.nlm.nih.gov/gene/42066

It's the cheerio gene from Drosophila melanogaster, also known as joy :)

No trump? 😥😥😭😭😭😭😭😭😭

Amazing ! i wish i have ideas like that from time to time,, well done :)

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Actually there was no gene with her name, not even close :)

Thanks for stopping by and for the resteem!!!

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It is inspring to see some people still put effort to their content ! and did I mention that BETTER THAN @SUESA

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@suesa is traveling across Europe, eventually making her way to Eastern Europe :D
Which would explain her lack of ...internet >:)