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I won't call it direct. It is more like over the time it gets accumulated and wrecks havoc. Like think of that zebra, when it runs from the predator. It heartbeat is fast, pumping the blood to supply muscles. But once the predator it mellows down. However if it doesn't mellow down, you increase the portability of wounding the blood vessels. The wound repair mechanism brings along with with inflammation, foam cells and scarring here and there. Have this a lot and you have artheosclerosis. In a similar manner have allostasis during stress alters metabolism and psysiology in way I will discuss in part 2. Have that a lot and you have metabolic diseases sprouting out. Now given there are individual differences in how tolerant people are to stress, there does exists multiple variables to it. Hence it is ought to be multifactorial. Nevertheless, a perpetrator.

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