RE: Childhood stressors and the beginning of pathogenesis chain reaction (Part 2 - We carry the baggage of our childhood)
Hey Scienceblock, awesome work!
Resteem!
By the way metabolites from the mitochondria also cause epigenetic modifications. At the one hand, they could act as inhibitors or activators for chromatin remodeling. On the other hand, citrate can be converted by ATP-citrate-lyase to create acetyl-CoA which serves for histone acetylation.
Read more about his here, here, here and here.
The question is just what these intermediates and metabolites do outside of the mitochondria. Probably they are there because of damage in the respiratory chain caused by ROS. Another explanation could be a Crabtree effect thus catching the necessary resources for an optimal mitochondrial function. Therefore, the mitochondria try to rescue the cellular chemistry by sending metabolites for reprogramming?????
I don't know.
Very exciting field!
Waiting for the next article
Regards
Chapper
Wow interesting. This I formation would be really useful to me. Not only because of its implication but because we have this side project going on where we are trying to correlate mitochondrial functional hetrogenity to how cell response to different ligands. I am gonna dig into this literature a bit. Thanks for sharing this.
No trouble,
sharing good information is my goal. Apparently, it is your goal as well!
Therefore, thank you very much again.
Have a nice weekend
Best
Chapper