Thank you for your kind and fruitful comment. In the reviewed article, it has stated two more emerging hallmarks that are evading immune destruction and reprogramming energy metabolism based on Otto Warburg concept of “aerobic glycolysis” which are beautifully explained in it. Therapeutic intervention based on the immunologic study of cancer has become the field of great interest for the researcher as well as a pharmacist. Although recent immunomodulatory therapy has promise the less side effect and efficacy it has of less use because this is less affordable for long run especially in the less developing country like Nepal. As you mentioned specific mutation and target based chemotherapy are practice in the recent year. Let's hope better newer drugs will be synthesized in near future for cancer treatment.