I choose to be a meliorist and hope that we won't die off! But generally, imagining what humans will be like in such a long time is nigh impossible. But I think one thing is certain: if we survive, we'll definitely be metahumans. Cos humans never stay stuck at one point. It's either forward, or back. Back means extinction. So if we survive by then, we'll definitely be something else entirely from what we are now.