This gene is highly expressed in animals and humans fed a low-calorie diet and it does seem to be linked with living longer.

I know you are highlighting resveratrol, but it is linked in the study to reduced caloric intake. What role is it suggested that reduced calories plays in increased lifespan?

Some months ago @scienceblocks wrote a post The quest for elixir of life - understanding caloric restriction (episode 1 - DNA damage and repair), and others have also written about caloric restriction. This seems to be a trend. However, when I look up studies that correlate body mass to mortality, reduced body mass does not seem to insure greater longevity. Here are two studies I just looked up:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499607/

https://www.ncbi.nlm.nih.gov/pubmed/24561114

How to reconcile these studies with data that shows caloric restriction increases lifespan?

I guess I resist the caloric restriction theory because I don't like to be hungry :)

That's a really comprehensive discussion of genes, RNA and DNA! Thank you,