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RE: The legacy economy failed me. So did government programs. But then Steemit came along, and things got better
Cluster headaches are no joke. While I have not suffered from them I have seen what they do to people. I hope things like Bromo become approved.
Right you are, @iamwne. I'm not holding my breath on BOL-148 approval, though. At this point, it is probably easier to make the stuff than obtain it from a reputable source. Unfortunately, that's cost-prohibitive, environmentally problematic, and carries significant legal risk.
And yet ... if I knew for a fact that it would rid me of this condition, I'm pretty sure all of that would seem worth it. But I can't know that, because the stuff is impossible to obtain.
The Germans seem to have had some luck with it in a short run trial. It is funny that they are simply adding to the weight of the atom of the D-lysergic acid to deal with the psychotropic aspects. It is not much different than what is done with SSRIs to make a new patentable medication. But if they knocked a few carbons off it would essentially be DMT in synthetic form and be a whole different type of psychotropic medication. If they can approve these minor changes to the molecule and there is an evidence basis then it seems silly not to approve it. All drugs really have to show at least 30% above the margin of placebo to be new meds but if you do minor changes it is okay? I really hope the best for you.
Right. But that non-psychoactive bit produced by adding bromine is important. While tripping is generally more pleasant than the crippling pain of a headache attack, it tends to be problematic when attempting to engage in many everyday life activities.
Technically IIRC sumatriptan (which can provide some relief during an attack at the cost of preventing a cluster headache cycle from tapering off) is itself a DMT analog. Brains are weird.
Isn't remarkable how many things have DMT in them? It is everywhere and not only primitive to serotonin but also tryptophan. Thinking about DMT years ago and while writing an article about the molecular basis of Traditional Chinese Medicine and Ayurveda got me thinking about the problems of selective synthesis. For eons plants and animals have developed all kinds of sympathetic compounds that selective synthesis reject. This may give some cause to explain the more prophylactic of TCM and Ayurveda and and the effectiveness of patent medicines in acute situations. Psychopharmacology is filled with agonists that cause all kinds of problems for people in terms of adverse reactions and even metabolic failure. Nature has worked many of these things out. But profit and politics stand in the way for many effective treatments. Things like Orthomolecular medicine seem to have at least a margin of credibility over placebo but what doctor is going to tell you that your schizophrenia can be cured by a complex of vitamins and whole foods? It sort of grieves me that students in medicine get more applied pharmacology and less actual biochemistry and I really think the days of a good oral history are gone. Your performance is graded on what boxes you check off on the EMR and what your proscribing levels are as compared to actual quality of life for patients. And we wonder why healthcare is so expensive. But I should get down off of my soapbox for a while and wish you a good night.