Please consider Entheogens.

A potential regimen:
Begin by 'microdosing' with psilocybin (cubensis mushrooms)
.25 grams every 3rd day, powdered in gelcaps they go down easier.
A month in, pick a quiet weekend and calm surrounding, and try 3 grams.
(read up on other people's trip reports @ Erowid)

Step regular 3rd-day doses up to .5 grams after this.

This has the potential to provide long-lasting gains in overall mood, lessen depression, smooth out brain chemistry swings and gain a sense of perspective.