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RE: The Lifespan of Flies Has Been Extended By Promoting Mitochondrial Replication
Great Post. I know a ton of age longevity work has been done in C. elegans. Some of the work is really cool, but a lot of it boils down to a lab discovering that overexpressing/deleting a gene increase lifespan followed by 10 years of chasing that one phenotype.
Indeed, at least with flies the organismal complexity is a bit higher. I just find the work fascinating. The real way to test this stuff is just to try the overexpressions in other models, and if they don't yield similar effects, move on. Rather than getting bogged down chasing a ghost.