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RE: Paracetamol-induced Liver Toxicity: The thin line between Taking a pain killer and destroying your Liver
Great post and your explanation of the physiology and pathophysiology are on point.
I agree with your doses on chronic use and toxicity but I I've never seen a value of 6g/ day as a toxic limit acutely?
The normally quoted toxic limit is about 150mg/kg which is about 12 grams in the average adult. Even this is quite a conservative figure.
Thanks again :)
Hi @tfcoates, thanks for dropping by and sharing your thoughts. From the information I have, the toxic limit varies in different individuals. For some, the sulfation pathway gets saturated at values close to 6g, while some individuals can take much higher doses.
Awesome, thanks for the clarification! I agree, best to play it safe. Always a good idea to avoid a lawsuit :p