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RE: Anti Anxiety Medication Found To Stop A Protein Involved In Pancreatic Cancer Development
Wow this post was tough. Had to read it twice to really get everything (or at least to think getting everything). This is good news. What is the next step? Human tests?
Just a silly question now. Do you know why the error bar for the compound-1 (let's assume I guessed the naming scheme :p) is so large compared to the others. Not that it matters (since from the next figure, this compound seems to be pretty inert), but by curiosity.
There was one more figure in the paper where they stopped the growth of human tumors grafted onto mice with Trifluoperazine as well. I thought about including it too, but wanted to keep this shorter. So as far as their next step I would suspect more direct tests in animal models (rather than cell culture). However as this looks not to be done by one of the pharmaceuticals (it's a variety of universities in Spain and hospitals, I don't see any pharma) so I am not certain what the pipeline would be. They did not discuss a next step for their finding, just that they observed the efficacy of Trifluoperazine for this case.
Why is the error bar so big for compound-1? Good question. I do not know, they are reporting standard deviation rather than SE so one terrible replicate (where all the cells died) could really throw massive error into the mix (especially considering things were only done in triplicate).
This was a difficult paper for me to read and interpret as the authors were not always entirely clear (which is surprising considering its in a nature sub journal) as to what was what.
I really dislike the non-disclosure of what the compounds were.
Often the best articles are not the clearest... It may also depend on the referee...
Thanks anyhow for your answer :)
Of course!