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RE: Nevada Woman Dies of "Superbug" Resistant to All Antibiotics Available In The United States

in #science7 years ago

I've yet to see an actual study done on even an animal model showing that the doses required to achieve bacterial death, are not toxic to humans. There is data showing that leaching of silver ions from the surface of colloidal nanoparticulate silver can occur and that ionic silver can have a variety of negative effects on body biochemistry.

I have seen studies where researchers have exposed cell cultures and seen no issues however this is not even the first stage in dealing with a potential drug candidate and proving it's safety. Many compounds seem perfectly safe against cellular cultures, but given to model organisms, can lead to disastrous effects, some not seen in the short term.

I remain skeptical.

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Thanks, @justtryme90, for your thoughtful reply.

I don't immediately have a complete response to the issues you've raised here. However, here are a couple of items that address the toxicity issue FYI:
  https://www.atsdr.cdc.gov/ToxProfiles/tp146.pdf
  http://www.info-archive.com/colsil%20silvertox.htm
Most of the issues reported therein are related to extreme dosages, and/or to silver compounds (in contrast to elemental and / or ionic silver).

Of course, toxicity is a major issue for "conventional," thoroughly studied antibiotics:
  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3175508/
  https://www.drugs.com/article/antibiotic-sideeffects-allergies-reactions.html
And if the alternative is "death," (as in your headline), is it unreasonable to use something "unstudied" but with no reported serious adverse affects (other than, in some cases, cosmetic)?

If I locate any studies more responsive to your concerns, I'll be sure to pass them along. ;)

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