Cancer Will Be Gone In Next Decade! But How?
It will be possible thanks to breakthrough in the field of nanomedicine. Arizona State University scientists, in collaboration with researchers from the National Center for Nanoscience and Technology сreated nanorobots to treat cancer tumors.
How Nanorobots work?
They made with, so called, DNA origami Technique. It enables the bottom-up self-assembly of micrometre-scale, three-dimensional structures with nanometre-precise features.
Each nanorobot is made from a flat, rectangular DNA origami sheet, 90 nanometers by 60 nanometers in size. A key blood-clotting enzyme (Thrombin) is attached to the surface of nanorobots. Thrombin can block blood flow, by clotting the blood within the vessels. If we will clog vessels which are supplying blood to the tumors, then tumor cell will simply die, due to lack of energy supply. Studies have shown that mice infected with tumors reacted positively to the nanorobots treatment within 24 hours and in 72 hours most of the tumors cells were dead. In order to program a nanorobot only attacks cancer cells, scientist DNA-aptamer.
- Aptamers are oligonucleotide or peptidemolecules that bind to a specific target molecule. Aptamers are usually created by selecting them from a large random sequence pool, but natural aptamers also exist in riboswitches. Aptamers can be used for both basic research and clinical purposes as macromolecular drugs. Aptamers can be combined with ribozymes to self-cleave in the presence of their target molecule.
The DNA aptamer could specifically target a protein, called nucleolin, that is present in high amounts only on the surface of tumor endothelial cells. (and are not found on the surface of healthy cells)
Once bounded to tumor's blood vessel surface, nanorobots were programmed to deliver an enzyme called thrombin that is key to blood clotting.
true @alxmuh ! I really wish that Cancer is remembered as a constellation rather than a disease :-D
Just yesterday I read this paper! It is very exciting to see that this method was succesful. It is only going to be a matter of time until we are able to properly treat cancer given the enormous progress in this field. Have you heard about the cancer vaccine? I recently wrote about this vaccine which was able to kill solid tumours in mice. Due to these promising results, human clinical trials are next. Maybe you like to check it out.
I surely will!
Glad I stumbled across this article. Quality read. Upvoted and followed!
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