😷😷RESEARCHERS UNCOVER NEW ANTIBIOTICS RESISTANCE GENES😷😷

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Metallo-β-lactamases are bacterial enzymes that provide resistance to carbapenems, the most potent class of antibiotics, Professor Kristiansson and colleagues said.

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These enzymes are commonly encoded on mobile genetic elements, which, together with their broad substrate spectrum and lack of clinically useful inhibitors, make them a particularly problematic class of antibiotic resistance determinants.

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It was hypothesized that there is a large and unexplored reservoir of unknown Metallo-β-lactamases, some of which may spread to pathogens, thereby threatening public health.

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The aim of the study was to identify new Metallo-β-lactamases of Class B1, the most clinically important subclass of these enzymes.

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The study shows that there are lots of unknown resistance genes. Knowledge about these genes makes it possible to more effectively find and hopefully tackle new forms of multi-resistant bacteria, Professor Kristiansson said.

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The more we know about how bacteria can defend themselves against antibiotics, the better are our odds for developing effective new drugs, added study co-author Professor Joakim Larsson, from the University of Gothenburg.

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The next step for the team is to search for genes that provide resistance to other forms of antibiotics

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