Chrys.: This parable is delivered against those who will not assist their neighbours either with money, or words, or in any other way, but hide all that they have.

The man in travelling into a far country is our Redeemer, who ascended into heaven in that flesh which He had taken upon Him. For the proper home of the flesh is the earth, and it, as it were, travels into a foreign country, when it is placed by the Redeemer in heaven. (Greg., Hom. in Ev., ix, i) He travels, not according to His divine nature, but according to the dispensation of the flesh which He took upon Him. For He who says to His disciples, “Lo, I am with you always, even unto the end of the world,” [Matt 28:20] is the Only-Begotten God, who is not circumscribed by bodily form. By saying this, we do not disunite Jesus, but attribute its proper qualities to each constituent substance.
We may also explain thus, that the Lord travels in a far country with all those who walk by faith and not by sight. And when we are absent from the body with the Lord, then will He also he with us. Observe that the turn of expression is not thus, I am like, or The Son of Man is like, “a man travelling into a far country,” because He is represented in the parable as travelling, not as the Son of God, but as man. (Origen.)

Greg.: The five talents denote the gift of the five senses, that is, the knowledge of things without; the two signify understanding and action, the one talent understanding only.

This lesson from this Gospel warns us to consider whether those who seem to have received more in this world than others shall not be more severely judged by the Author of the world; the greater the gifts, the greater the reckoning for them. Therefore should every one be humble concerning his talents in proportion as he sees himself tied up with a greater responsibility.

Further reading: http://dhspriory.org/thomas/english/CAMatthew.htm#25