When do You Detach from a Lost Investment?

Q and A blog about when should you detach from a lost investment;

1: at what point, after discovering the down and out of an investment, do people start liquidating, and when does it end?

2: Upon reaching max efficiency in your horizon of a project, do you re-evaluate, start something new to make baskets, and re-circuit back to the for-noted project?

3: What is your opinion on taxes?

4: Open seas trading, or monorailed, or in between?

5: Reader's choice, feel free to ask your own questions of the masses, skynet amungst others, is watching.