I have always been curious in ayahuasca but isn't the main active ingredient a form of DMT? I believe pure DMT is the most potent pure form of the active ingredients in most psychoactives. What I would be even more interested in is how ayahuasca or DMT physiologically actually affects the pineal gland and how that translates to the expression shown in a subject during a trip in their mind and body.
I believe some places in the U.S. have been more open about having ceremonies involving ayahuasca hopefully that can grow as it becomes more mainstream , I might actually consider experimenting one day lol.