This was a year of exploration for me. Exogenous plant ligands, such as CBD, interact with endogenously produced proteins, receptors, enzymes, and endogenous ligands in the endocannabinoid system, an ancient physiologically conserved system estimated to be 600 million years old. Surprisingly, this chemical was considered for inclusion in marmalade. I saw it recently https://www.tillmanstranquils.com/product-category/cbd-gummies/. Unfortunately, concerns over its abuse led to its prohibition in the United Kingdom in 1928 and the United States in 1937. I'm going to wait until it's legalized!