The first games are indeed difficult for both the bookie and the gambler. I could go for Anderlecht, Club Brugge and Genk for the 1X2 but I do think that Antwerp will also start great. So it is a calculated gamble!
Also I do think that there is no use in placing multiples if the odds don't go above 2. If that would be the case, singles would be the saffer betting type!