Despite coming up with this topic, I'm really struggling with finding the one NPC that is my fave.

sigh bapanada (I've been playing a lot of Hollow Knight)

From the map fish in Zelda Wind Waker to the item vendor in Resi 4, there are just so many to chose from.

But I gotta go with Cayde-6 from Destiny.
Voiced by Nathan Fillion, after Bungie really started to use the npc's in Taken King, he quickly became my favorite.

And now he's going to die in the coming expansion for Destiny 2.
Rest in peace sweet prince!