Well its true that many get crushed by their challenges, but I live with a very simple rule,
See in music production, when something isn't going right, no matter how one tweaks it, the best practices are to;

1. Start all over
2. Change some fundamentals.

This two point above is basically how I handle life.
Its never too late to start over, its never too late to change a fact.
Challenges or not, the only time a person fails is when he gives up or dies.