EGCG, Quercetin, NAC: Potentially beneficial to help SARS-CoV-2 ventilator patients fight off the viral infection?

in #news2 years ago

"In this report, we demonstrated that EGCG and theaflavin, the main active ingredients of green tea and black tea, respectively, are potentially effective to inhibit SARS-CoV-2 activity. Coronaviruses require the 3CL-protease for the cleavage of its polyprotein to make individual proteins functional. EGCG and theaflavin showed inhibitory activity against the SARS-CoV-2 3CL-protease in a dose-dependent manner"
https://pubmed.ncbi.nlm.nih.gov/32963564/

Epigallocatechin-3-Gallate (EGCG) Inhibits SARS-CoV-2 Infection in Primate Epithelial Cells
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919953/

"quercetin has the ability to inhibit the main protease of SARS-CoV-2, known as Mpro or 3CLpro (3C-like protease)"
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8066963/

Factual insights of the allosteric inhibition mechanism of SARS-CoV-2 main protease by quercetin: an in silico analysis
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7802979/

"NAC has antioxidant, anti-inflammatory and immune-modulating characteristics that may prove beneficial in the treatment and prevention of SARS-Cov-2."
https://pubmed.ncbi.nlm.nih.gov/33177829/

"In vivo, in vitro, and human clinical trials have demonstrated N-acetylcysteine (NAC) as an effective method of improving redox status, especially when under oxidative stress. In human clinical trials, NAC has been used to replenish glutathione stores and increase the proliferative response of T cells."
https://pubmed.ncbi.nlm.nih.gov/32504923/

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