Artesunate, Curcumin, Cannabidiol, Glycyrrhizin: Potentially beneficial to help SARS-CoV-2 ventilator patients fight off the virus infection?

in #news2 years ago

"artesunate targeted SARS-CoV-2 at the post-entry level."
https://pubmed.ncbi.nlm.nih.gov/34272426/

"arteannuin B and lumefantrine acted at the post-entry step of SARS-CoV-2 infection. This research highlights the anti-SARS-CoV-2 potential of artemisinins and provides leading candidates for anti-SARS-CoV-2 drug research and development."
https://pubmed.ncbi.nlm.nih.gov/32786284/

"Our results suggest that curcumin affects the SARS-CoV-2 replicative cycle and exhibits virucidal effect with a variant/strain independent antiviral effect and immune-modulatory properties."
https://pubmed.ncbi.nlm.nih.gov/34833991/

"cannabidiol (CBD), a compound produced by the cannabis plant, inhibits SARS-CoV-2 infection. CBD and its metabolite, 7-OH-CBD, but not congeneric cannabinoids, potently block SARS-CoV-2 replication in lung epithelial cells."
https://pubmed.ncbi.nlm.nih.gov/33758843/

"Cannabidiol (CBD) can prevent the inflammatory response of SARS-CoV-2 spike protein in Caco-2-cells. This action is coupled with the inhibition of IL-1beta, IL-6, IL-18, and TNF-alpha, responsible for the inflammatory process during SARS-CoV-2 infection."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987006/

Glycyrrhizin Effectively Inhibits SARS-CoV-2 Replication by Inhibiting the Viral Main Protease
https://pubmed.ncbi.nlm.nih.gov/33918301/

"Importantly, Glycyrrhizin inhibited SARS-CoV-2 replication in Vero E6 cells without exhibiting cytotoxicity at high doses. The dual ability of Glycyrrhizin to concomitantly halt virus replication and dampen proinflammatory mediators might constitute a viable therapeutic option in patients with SARS-CoV-2 infection."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953444/

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