Understanding ALK Gene Rearrangements In NSCLC

in #mrmed • last year

The complicated illness known as non-small cell lung cancer (NSCLC) is fueled by a number of genetic mutations that promote tumour development. Anaplastic lymphoma kinase (ALK) gene rearrangements have been identified as a critical driver mutation in a fraction of NSCLC patients among these changes. ALK is a gene that codes for a receptor tyrosine kinase; when this gene is rearranged, ALK signalling pathways may become constitutively active.

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