Not only a diet can affect the risk of atherosclerosis, but it is also affected by stress levels, alcohol consumption, physical activity.
My friend, who is a kind of bodybuilder, bought some fat-burning pills. There was information on the box. It suggested to drink at least 2 liters of water daily and run (or walk) at least 3 miles to increase the effect and reduce possible indispositions. In this case, I suppose that any can become slim without these pills.
It seems to me that EBM approach can help in the diagnosis, but solveting of the problem should be tailor-made.